Abstract
THE experiments here reported were conducted tq determine the alteration in the distribution and concentration of radioiodine in the pituitary, adrenals, thyroid, muscle and blood of rats maintained on prolonged high iodine intake, on desiccated thyroid and on propylthiouracil and to determine whether these conditions influence the local clearance of I131 after intramuscular injection. methods Five groups of five young, female albino rats (Groups I-V) were given graded doses of Lugol’s solution daily in their drinking water over a period of 120 days. Five animals (Group VI) received no Lugol’s solution over the same period. Drinking containers were emptied and washed daily and replaced with from 1 to 5 drops of fresh Lugol’s solution in 100 ml. of tap water (approximately 0.9 to 4.3 mg. of iodine daily for each rat). Rockland rat ration was provided, supplemented weekly with fresh vegetables.
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