Abstract
Inter-patient radiation sensitivity variability has recently been shown to have a genetic component. This genetic component may play a key role in explaining the fluctuating rates of radiation-induced toxicities (RITs). Single nucleotide polymorphisms (SNPs) have thus far yielded inconsistent results in delineating RITs. Copy number variations (CNVs) have been implicated in inflammatory diseases but not yet investigated in RITs. Moreover, clinical and dosimetric factors may present confounding effects, therefore, we explore a radiogenomic modeling approach to investigate the association of CNVs and SNPs, along with other clinical and dosimetric variables, in hypofractionated radiation induced rectal bleeding (RB) and erectile dysfunction (ED) in prostate cancer patients treated with curative irradiation.
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