Abstract
Radiobiological parameters, cell killing, induction of mutations resistant to 6-thioguanine and to methotrexate, and DNA scissions were investigated at the plateau region and peak region of the pion beams of TRIUMF under a preclinical beam condition. The relative biological effectiveness (RBE) of four parameters at the plateau region were nearly 1 using gamma-rays or X rays as the standard radiations. RBE values at the peak regions were varied from one biological parameter to the other. The RBE of cell killing was dependent upon radiation dose; an RBE of 1.9 decreased gradually to 1.2 with an increased radiation dose. The RBE of mutations resistant to 6-thioguanine was dose-dependent and decreased from 1.7 to 1.3 when the dose was increased, while the RBE of mutations resistant to methotrexate was a constant, 1.0. The RBE of DNA scission was a constant 0.7. The radiobiological significance of cell killing and of mutagenesis in pion radiotherapy will be discussed.
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