Abstract
The importance of Rac1 in the enucleation process of erythroid cells has previously been reported. We found that an inhibitor of Rac1 (NSC23766) could inhibit the enucleation of mouse erythroid progenitor cell line, MEDEP-BRC-5, which can differentiate into enucleated erythrocytes. It is known that Rac1 plays a central role in activating NADPH oxidase complex and NADPH oxidase produces superoxide in response to various signals and stresses. Among them, X-ray irradiation can induce production of superoxide in cells.
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