Abstract
Mutant oncogenes could enable clonal dominance by cell-intrinsic means or by suppressing nearby wild-type stem cells. Reporting recently in Nature, three groups demonstrate potent neighborhood effects, both within intestinal crypts (Flanagan etal., 2021; van Neerven etal., 2021) and across crypts through intermediary sub-epithelial trophocytes (Yum etal., 2021).
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