Abstract
To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. The T stage showed a significant correlation with RAB27A intensity (p<0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036). RAB27A is an independent prognostic factor in CCRCC.
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