Abstract
Quinoline, which belongs to N-heterocyclic compounds, occurs naturally in the environment and is used in numerous industrial processes. The structures of various chemicals, such as dyes and medicines, are based on this compound. Due to that fact, quinoline and its derivatives are widely distributed in environment and can exert toxic effects on organisms from different trophic levels. The ability of the filamentous fungus Cunninghamella elegans IM 1785/21Gp to degrade quinoline and modulate the membrane composition in response to the pollutant was studied. C. elegans IM 1785/21Gp removes quinoline with high efficiency and transforms the pollutant into two novel hydroxylated derivatives, 2-hydroxyquinoline and 3-hydroxyquinoline. Moreover, due to the disruption in the membrane stability by quinoline, C. elegans IM 1785/21Gp modulates the fatty acid composition and phospholipid profile.
Highlights
Quinoline, which is classified into N-heterocyclic compounds, is a pollutant widely distributed in environment
Preliminary stages of research included the evaluation of C. elegans IM 1785/21Gp growth in the presence of quinoline and the assessment of quinoline elimination
The analysis revealed that C. elegans IM 1785/21Gp exhibited high tolerance toward quinoline (Fig. 1)
Summary
Quinoline, which is classified into N-heterocyclic compounds, is a pollutant widely distributed in environment. Biotransformation of quinoline by bacteria is a well-known process with reference to its conditions and metabolites formed during the conversion. Various bacteria, especially those belonging to the genus Pseudomonas, possess the ability to tolerate and degrade quinoline (Cui et al 2004; Zhu et al 2008; Bai et al 2009; Sun et al 2009; Lin and Jianlong 2010). Few works describe the conversion of quinoline by fungi, which commonly occur in many environments and are extensively studied as degradation models of persistent pollutants. Fungi belonging to the genus of Cunninghamella are well
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