Abstract

and high risk in 31 (38%), 43 (53%), and 7 (9%) pts, respectively. Median prescription dose was 50.4 Gy in 1.8 Gy fractions. The observed 10-year rate of IHD was 1.4% (95% CI Z 0.2-9.4). MRE for IHD with ABC and FB were 3.56% (95% CI Z 2.78-4.33) and 4.31% (95% CI Z 3.35-5.28), respectively [Table]. Cardiac testing was performed in 15 (19%) pts due to signs and symptoms of IHD: 1 of 3 pts had occlusive CAD on angiography, 1 of 7 pts had ischemic signs on stress testing, and 8 pts had normal stress myocardial perfusion single photon emission tomography (SPECT) imaging. Conclusions: The rate of IHD at 10 years was 1.4% in this first report of cardiac outcomes following RT with ABC. While limited by small study size, the low prevalence of abnormal cardiac testing corroborates findings. Using MRE, RT with ABC reduces the risk of IHD when compared to FB with the largest benefit observed for AHA high-risk pts. In appropriately selected pts, RT with ABC can provide a clinically significant reduction in the risk of IHD in survivors of LBC. Author Disclosure: H.B. Eldredge-Hindy: None. D. Duffy: None. K. Yamoah: None. A.P. Dicker: None. J. Skowronski: None. N.L. Simone: None. P.R. Anne: None.

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