Abstract
Purpose To examine the effects of quercetin on healing of experimental colon anastomosis injury in early and late period.Methods Eighty male Wistar-Albino rats were divided into 8 groups. For all groups, left colons of the rats were resected and for the rest end-to-end anastomosis was performed. Two of the groups for which the experiment protocol was ended on the 3rd and 7th day following the anastomosis were not administered with either quercetin or dimethylsulfoxide DMSO, whereas two other groups were administered with DMSO only, and four other groups were administered with quercetin dissolved in DMSO in doses of 20 and 100 mg/kg during the protocol. At the end of the study, anastomosis line was resected, histopathological evaluation was performed and bursting pressure, malondialdehyde, superoxide dismutase, catalase, and hydroxyproline levels were measured.Results Quercetin significantly increased hydroxyproline, superoxide dismutase, catalase levels, histopathological healing score, bursting pressure values and decreased malondialdehyde level in early period. It also significantly increased superoxide dismutase, catalase, and hydroxyproline levels and decreased malondialdehyde level in late period.Conclusion It was seen that quercetin speeds up the injury healing process and reveals an antioxidant effect, specifically in early period.
Highlights
Colon cancer is ranked third among all types of cancers as regards to incidence, whereas it is the second leading cause of cancer-related deaths[1]
We examined the effects of the treatment on healing of surgical injury and antioxidant enzyme activities on early period and late period
Bursting pressure levels in 3 days groups, which represent the early period of anastomosis injury healing, were recorded as 32.1±8.4, 33.5±5.1, 67.6±9.5, and 79.4±8.0 for groups C3, DMSO3, Q3/20, and Q3/100 respectively
Summary
Colon cancer is ranked third among all types of cancers as regards to incidence, whereas it is the second leading cause of cancer-related deaths[1]. Surgical intervention has an important role in treatment methods. Despite the developments in surgical techniques and the application of new technologies such as robotic surgery, there are still cases which end up with death after colon anastomosis when the anastomosis area cannot heal completely and there is a leakage[3,4]. Anemia, malnutrition, tension in anastomotic line, surgical technique, localized infection, and obstruction in distal anastomosis may be listed among the possible causes of anastomotic leaks[3,5]. Anastomotic leaks can still be observed at a rate of 1-19.2% after colorectal surgery interventions despite the developments in surgical techniques[3,4,6]
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