Abstract
The finding determines the dependence of body processes on STP and MCT, six processes which occur in the isolated rabbit ileum were used to prove the statement of the theory 1 of BUTT, mainly effects of extract and Autonomic drugs on isolated rabbit ileum together with novel mathematical principles were used to show that seven normal processes (motility, secretion, metabolism, circulation, immunoreactivity, absorption, digestion) of the isolated rabbit ileum are directly proportional to activated STP and MCT and inversely proportional to inactivated STP and MCT. Acknowledge that from the above relation, STP responses Rs was used base on the assumption that all body processes are responses of STP and MCT, in other words, body processes are manifestation of STP response, thus First and foremost, I posit that any number of response (Rsn) or magnitude of response (Rsm) is a function of orproportional to activated STP backbones (Ni) and inversely proportional to inactivated STP backbone (Ny). To estimate Nifor each receptor in the isolated rabbit ileum, I determined number of molecules (N) for each drug and extract and number of molecules (Nx) towards the receptor direction, also using a biomarker (isolated rabbit ileum) the magnitude of effect (contraction and relaxation) of extract/drugs on the ileum was determined by combination interactions, novel mathematical equations and quantum physics, which gave me insight about the autonomic nature of the extract. Again from the combination interaction of antagonists and agonists with the extract as well as novel mathematical equation and calculation, I deduced the receptor types which combined with the extract, the couple receptor types, and the linked cascades in un limited sense of their complexity, in spite that past finding have unraveled various receptor types, limitations of characterization and crystallography abounds and so warrant use of mathematic to gain useful insight, interestingly, observed height, STP components’ flux time and mathematically determined magnitude of response (Rsm), shows strong correlation, of course as found in other findings, we assumed that alternating responses seen was due to bimodal on or off switches peculiar to STPs and MCT, these act in turn to activate many targets and therefore more than two responses might have occurred as predicted from various novel equation and calculation. The seven processes investigated are; directly; motility, indirectly; secretion, epithelial protein synthesis and transluminal absorption, digestion, circulation, and immunoreactive processes respectively, as a matter of veracity, it important to state that only the result of isolated rabbit ileum motility was obtained from which other processes were inferred from perspective of STP and MCT vital cascade components using platform of mathematics, in so far as this remain the case, the principle of hypothesis was investigated and lead to the emergence of Boy’o Universal Theory of Therapy (BUTT) 1, Theory 1 of BUTT called dependence theory states that any process; pathologic, physiologic, biochemical, genetic, metabolic and congenital occurring in the body, including drug efficacy and drawback, is directly proportional to activated signal transduction pathways (STPs) and inversely proportional to inactivated ones provided that MCT remains constant. The result was subject to both statistical analysis and mathematical calculation, for the statistical result standard deviation was 1.05 and magnitude of response (Rsm) was 27.996 at number of active components (Nc1) of 0.7 to indicate inactivation of STPs, other values show activation, a fact that is of clinical, pharmacological, and biomedical importance.
Highlights
The finding test the hypothetical statement of theory 1 of Boy’o universal theory of therapy (BUTT 1), it maintained that any process in body depends on signal transduction pathways (STP) and Molecular cross talk (MCT) interaction, signaling medium enumerated in most literature shed light on genesis of various processes in the body [1], be they binding or non binding actions, STP encompass complex interrelated series of communicating cascades of proteins and enzymes, each cascade have particular attributes which they utilized in processes of transduction, they transmit signals by assigning roles to each cascade components and in this regard, adapter, recruiter, Received May 08, 2015; Accepted August 10, 2015; Published August 17, 2015Citation: Sani M (2015) Quantum Physics and Mathematical Aided Proof of Theory 1 of Boy’o Universal Theory of Therapy (BUTT)
The finding test the hypothetical statement of theory 1 of Boy’o universal theory of therapy (BUTT 1), it maintained that any process in body depends on STP and MCT interaction, signaling medium enumerated in most literature shed light on genesis of various processes in the body [1], be they binding or non binding actions, STP encompass complex interrelated series of communicating cascades of proteins and enzymes, each cascade have particular attributes which they utilized in processes of transduction, they transmit signals by assigning roles to each cascade components and in this regard, adapter, recruiter
The signal transduction of most receptors types and subtypes activated in seven GIT processes (Motility, secretion, metabolism, absorption, immunoreactivity, circulation and digestion) of the isolated rabbit ileum which have bearing to the bioassay had been described by past findings, it was possible to asses STP cascade involves in the seven processes with aid of quantum physics and mathematics principles and go ahead to prove that their occurrence would not have been without the presence of STPs, actual experiment use motility processes, from which together with mathematical principles other STPs mediated processes were determined, Morrison and Davis, [4] shows that MPKs pathways are positively regulated by several mechanisms which include scaffold proteins
Summary
The finding test the hypothetical statement of theory 1 of Boy’o universal theory of therapy (BUTT 1), it maintained that any process in body depends on STP and MCT interaction, signaling medium enumerated in most literature shed light on genesis of various processes in the body [1], be they binding or non binding actions, STP encompass complex interrelated series of communicating cascades of proteins and enzymes, each cascade have particular attributes which they utilized in processes of transduction, they transmit signals by assigning roles to each cascade components and in this regard, adapter, recruiter, Received May 08, 2015; Accepted August 10, 2015; Published August 17, 2015. The signal transduction of most receptors types and subtypes activated in seven GIT processes (Motility, secretion, metabolism, absorption, immunoreactivity, circulation and digestion) of the isolated rabbit ileum which have bearing to the bioassay had been described by past findings, it was possible to asses STP cascade involves in the seven processes with aid of quantum physics and mathematics principles and go ahead to prove that their occurrence would not have been without the presence of STPs, actual experiment use motility processes, from which together with mathematical principles other STPs mediated processes were determined, Morrison and Davis, [4] shows that MPKs pathways are positively regulated by several mechanisms which include scaffold proteins The layout of this finding can be extrapolated to ones involving body abnormality and drug toxicity, given that STPs determine all processes of the body, body processes are manifestation of STP responses, instance gene transcription, contraction of heart muscle, cellular uptake of glucose etc. Imagine a world free of body abnormality, drug adverse effects (side effect, toxicity etc.), effective determination of Rsm values will form linked between used and gauging of STPs activities in biomedical research, drug development, drug safety profiles determination, and use of target hit in relation to treatment
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