Abstract
BackgroundTo investigate the safety and efficacy of 8Spheres in partial splenic embolization. To explore the possibility of accurate control of splenic embolic volume by quantifying the number of microspheres used during PSE.MethodThe data of 179 patients who underwent PSE were collected. The patients were divided into two groups: 300–500 um microsphere group (N = 83) and 500–700 um microsphere group (N = 96). The spleen volume before PSE, infarct volume and infarct rate of the spleen after PSE, changes in peripheral blood cells after PSE, postoperative adverse events and incidence of infection were compared between the two groups.Results300–500 um group vs 500–700 um group: postoperative spleen volume (cm3): 753.82 ± 325.41 vs 568.65 ± 298.16 (P = 0.008); spleen embolization volume (cm3): 525.93 ± 118.29 vs 630.26 ± 109.71 (P = 0.014); spleen embolization rate: 41.1 ± 12.3% vs 52.4 ± 10.1% (P = 0.021). Leukocytes and platelets were significantly increased after PSE in both groups; leukocyte, 1 month: 4.13 ± 0.91 vs 5.08 ± 1.16 (P = 0.026); 3 months: 4.08 ± 1.25 vs 4.83 ± 0.98 (P = 0.022); platelet, 1 month: 125.6 ± 20.3 vs 138.7 ± 18.4 (P = 0.019); 3 months: 121.8 ± 16.9 vs 134.3 ± 20.1 (P = 0.017). Incidence of abdominal pain after PSE, 72 (86.7%) vs 69 (71.9%), P = 0.027. The incidence of other adverse events and infections after PSE was not statistically different.ConclusionPSE with 8Spheres is safe and effective. The use of 500–700 um microsphere for PSE can make the increase of peripheral blood cells more stable. Each vial of 8Spheres corresponds to a certain volume of splenic embolization, so it is possible to achieve quantitative embolization in PSE.
Highlights
Hypersplenism is a clinical syndrome that is mainly characterized by splenomegaly and cytopenias
Some commonly used embolization materials for splenic embolization include microspheres, gelatin sponge particles, PVA particles and coils. 8Spheres is a new type of polyvinyl alcohol microspheres, which is composed of polyvinyl alcohol backbone, covalent bond form and cross-linking agent
Since the number of microspheres contained in each bottle of 8 spheres was fixed and moderate, it was explored whether the possibility of accurate control of splenic embolic volume could be achieved by quantifying the number of microspheres used during Partial splenic embolization (PSE)
Summary
Hypersplenism is a clinical syndrome that is mainly characterized by splenomegaly and cytopenias. Primary splenomegaly is rare in clinical practice, and the. Many studies have reported that the efficacy and complications of partial splenic embolization are related to the volume of splenic embolization. It has different particle size models and is loaded with 1 g microspheres in each bottle. Since the number of microspheres contained in each bottle of 8 spheres was fixed and moderate, it was explored whether the possibility of accurate control of splenic embolic volume could be achieved by quantifying the number of microspheres used during PSE.
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