Abstract
A purified pituitary gonadotropin containing predominantly FSH activity was administered in graded closes to hypophysectomized and intact immature female rats, with and without concurrent administration of diethylstilbestrol in large doses. A more striking and consistent ovarian weight increase to pituitary gonadotropin, brought about through stimulation of early ovarian follicle development, regulation of further follicular progression, and depression of interstitial tissue overgrowth was observed in the diethylstilbestrol-treated hypophysectomized animals.
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