Abstract

To propose a new method for quantitatively mapping the renal metabolic rate of oxygen (RMRO2) and to evaluate the proposed method using a caffeine challenge. Pseudo-continuous arterial spin labeling (pCASL) and QSM sequences were used to obtain MR images in the kidney. Six healthy volunteers were scanned on caffeine and control days. The pCASL and QSM images were registered using DICOM information and rigid translation. The Fick principle was applied to estimate RMRO2. The results on caffeine and control days were compared to evaluate the capability of the proposed method to estimate renal oxygen consumption. A paired t-test was used to assess the statistical significance. Estimated renal blood flow (RBF), QSM, and RMRO2 maps were consistent with those reported in the literature. RMRO2 values were higher than the cerebral metabolic rate of oxygen (CMRO2) and were significantly reduced on the caffeine days compared to the control days, consistent with findings from non-MRI literature. The feasibility of measuring renal oxygen consumption using pCASL and QSM images was demonstrated. To the best of our knowledge, this work provides quantitative maps of renal oxygen consumption in humans for the first time. The results were consistent with the literature, including the statistically significant reduction in renal oxygen consumption with caffeine challenge. These findings suggest the potential utility of our technique in measuring renal oxygen consumption noninvasively, especially for patients with complications associated with contrast agents.

Full Text
Paper version not known

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.