Quantitative evaluation of the changes of left ventricular short axial strain in patients with atrial septal defect before and after the transcatheter closure by two-dimensional speckle tracking imaging

Abstract

Objective To explore the short axial strain of left ventricle in patients with atrial septal defect(ASD) before and after the transcatheter closure by using two-dimensional speckle tracking imaging(2D-STI). Methods A total of 30 patients with ASD underwent echocardiography before and after the transcatheter closure. The procedure was performed to obtain the peak of circumferential strain(Sc) and radial stain(Sr) of left ventricle by 2D-STI. Thirty healthy volunteers were enrolled as controls. Results ①Compared with the control group, regional myocardial Sc of ASD group decreased(P<0.05). Sc of anterior septum (AS), anterior wall (AW), laterior wall (LW) and posterior wall (PW) increased (P<0.05) at 2-days after the transcatheter closure and those parameters were higher than control group. At the six-months after the transcatheter closure, those parameters reduced to the normal level (P<0.05). Sc of inferior wall (IW) and mid-posterior septum (MP-Sept) increased to the normal level at 2-days after the closure surgery(P<0.05). ②Compared with control group, regional myocardial Sr of ASD group decreased(P<0.05) except PW, two-days after the transcatheter closure these parameters increased to the normal level. Sr of PW in ASD group increased compared with control group(P<0.05), and there were no statistical changes at 2-days after the transcatheter closure. Sr of PW in ASD decreased (P<0.05) to normal level until 6-months after the transcatheter closure. ③Global circumferential strain (GCS) of left ventricular in ASD group were lower than control group (P<0.05). At two-days after undergoing transcatheter closure the GCS increased (P<0.05) and those parameters were higher than control group (P<0.05). Six-months after the transcatheter closure those parameters reduced to the normal level (P<0.05). There were no statistical differences of left ventricular global radial strain (GRS) between control group and ASD group. However, the GRS of ASD group increased (P<0.05) and those parameters were higher than control group (P<0.05) after 2-days undergoing the transcatheter closure. At six-months after the transcatheter closure those parameters were reduced to normal level (P<0.05). Conclusions 2D-STI can quantitative evaluate left ventricular circumferential strain and radial strain in patients with ASD before and after the transcatheter closure. Key words: Echocardiography; Heart septal defects, atrial; Closure; Two-dimensional speckle tracking imaging; Strain