Abstract
A simple, rapid, reliable and accurate HPLC method has been developed and validated as per the ICH guidelines for the quantitative determination of Donepezil HCl in bulk and tablets. The water HLC-10, high performance liquid chromatography system were used. The LOQ is detected at concentration 0.05mg/ml and the linearity range is 50-150g/ml. An optimum concentration scanned in the range 200-350 nm and ? max of the drug is 230 nm. No any interference at developed (R t = 8.22 min) and also the ? max peak is sharp. The Accuracy of the method was found to be in the range of 99.70% to 100.26%. The mean Inter and Intraday assay Relative Standard deviation (%RSD) were less than 0.69%. The Proposed method was found to be Linear, precise and accurate for the quantitative estimation of Donepezil in tablet formulations and can be used for commercial purposes.
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