Abstract
Gas chromatography has been used for analysis of aerosol propellants and active ingredients. The propellant analysis generally involved introduction of a previously vaporized sample into the gas chromatograph. Such methods become impractical when dealing with small aerosol packages such as those used for inhalation therapy. The purpose of this work was to develop methods for the accurate sampling and analysis of the propellants and cosolvents of such packages. These methods may also be extended to other volatile components of aerosol packages. Two sampling techniques were developed. These include the use of gas-tight sampling devices to either prepare solutions of the aerosol contents or to load a small-volume, high-pressure, liquid syringe. The volatile components were separated on a porous polystyrene bead column and the composition was calculated from peak areas.
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