Abstract
Background Perfusion imaging visualizes early changes within the ischaemic cascade and has been shown to accurately detect significant coronary artery stenoses. First pass myocardial perfusion CMR yields high spatial resolution and permits quantification of myocardial blood flow. However, perfusion-CMR has only been validated in a small number of previous studies and using relatively early perfusion methods. An isolated blood-perfused MR compatible porcine heart model which can be imaged by identical equipment used for humans has been recently proposed. The model permits full control of regional myocardial blood flow, thus providing a valuable tool for the validation of quantitative perfusion assessment.
Highlights
Perfusion imaging visualizes early changes within the ischaemic cascade and has been shown to accurately detect significant coronary artery stenoses
An isolated blood-perfused MR compatible porcine heart model which can be imaged by identical equipment used for humans has been recently proposed
After reperfusion the coronary flow rate was set by an external pump to accommodate stable sinus rhythm
Summary
Andreas Schuster1*, Amedeo Chiribiri, Masaki Ishida, Matthias Paul, Shazia Hussain, Niloufar Zarinabad Nooralipour, Geraint Morton, Roy Jogiya, Divaka Perera, Tobias Schaeffter, Sven Plein, Eike Nagel. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. From 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France. 3-6 February 2011
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