Abstract
As a well-known long non-coding RNA, HOTAIR has been demonstrated to be involved in carcinogenesis and progression of various human cancers. Previous studies have investigated the potential association between HOTAIR polymorphisms and cancer risk in Chinese population. However, the results remain conflicting. Therefore, for the first time, we conducted a meta-analysis to derive a more precise estimation of these associations for Chinese. PubMed, Embase, CNKI and Wanfang databases were systematically searched. Odds ratios with 95% confidence intervals were applied to assess the association between rs920778, rs4759314, rs7958904, rs874945 and rs1899663 polymorphisms of HOTAIR and cancer susceptibility. Heterogeneity, sensitivity analysis and publication bias were conducted to measure the robustness of our findings. A total of 21 eligible studies comprising 12,278 cases and 14,532 controls were analyzed. The pooled data showed that rs920778 polymorphism was significantly associated with an increased cancer risk in all five genetic models in Chinese population. As for rs4759314 and rs874945 polymorphisms, similarly increased risks were found in specific genetic models and stratified groups. However, significant decreases in cancer risk were observed for rs7958904 in the total population, as well as in subgroup analyses. In addition, lack of association was detected between rs1899663 polymorphism and cancer susceptibility. In summary, our meta-analysis implicates possible relationship between HOTAIR polymorphisms and cancer risk in Chinese population.
Highlights
Long non-coding RNAs, as a type of transcribed RNAs which are longer than 200 nucleotides with no protein-coding capacity, were initially claimed to be a fake transcriptional noise [1, 2]
The Long non-coding RNAs (lncRNAs) polymorphisms have been demonstrated to be involved in carcinogenesis and progression of different types of cancers
In 2016, three similar meta-analyses involving eight articles explored the association of HOTAIR polymorphisms with several kinds of cancers among worldwide population [34,35,36]
Summary
Long non-coding RNAs (lncRNAs), as a type of transcribed RNAs which are longer than 200 nucleotides with no protein-coding capacity, were initially claimed to be a fake transcriptional noise [1, 2]. It is becoming clear that lncRNAs are involved in a wide range of biological regulation in the carcinogenesis and progression of various human cancers [3,4,5,6]. It has been demonstrated that HOTAIR could interact with polycomb repressive complex 2 (PRC2) and LSD1/ CoREST/REST complex, in turn induce its relating methylation of histone H3K27 and demethylation of histone H3K4 respectively, and result in the alteration of genes expression profile [8, 9]. HOTAIR was shown to be involved in the progression of multiple types of cancers, indicating that HOTAIR might serve as a useful biomarker for tumorigenesis and progression [8, 14,15,16]
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