Abstract

Objective To assess the association between the programmed cell death-1 (PD-1) polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population. Methods We searched PubMed, MEDLINE, and CNKI databases and retrieved studies (2536 cases and 3491 controls) on the association of PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population. Meta-analysis was performed with Stata statistical package 12.0, with 95% confidence intervals and odds ratios calculated. Results Meta-analysis of all the included clinical trials showed that there was no significant association between the PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population in all the genetic models [homozygous (GG vs AA: OR=0.81, 95%CI=0.58~1.15, P=0.236); heterozygous (AG vs AA: OR=0.97, 95%CI=0.87~1.08, P=0.523); dominant (AG+ GG vs AA: OR=0.95, 95%CI=0.86~1.05, P=0.333); recessive (GG vs AG+ AA: OR=0.82, 95%CI=0.58~1.16, P=0.263); and allele (T vs C: OR=0.95, 95%CI=0.88~1.03, P=0.211)]. Conclusion There was no significant association between the PD-1 polymorphism rs10204525 and risk of upper gastrointestinal cancer in the Chinese population. Key words: Programmed cell death-1; Polymorphism; Upper digestive tract cancer; Risk; Correlation analysis

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