Abstract
A simple and rapid quantitative method for the derivati-zation and determination of lipophilic chloroethylnitrosoureas is described. This procedure involves the ether extraction of the chloroethylnitrosourea from plasma and conversion of the parent drug to an O-methylcarbamate by reaction in anhydrous methanol. The product O-methylcarbamate may be separated with gas chromatography (GC) and detected with nitrogen-specific GC detectors or with mass spectrometry using multiple-ion detection. The lower limit of detection for each method was ~100 ng/ml plasma.
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