Abstract
It is unclear if the dye-dilution theory and its corresponding parameters are capable of measuring brain perfusion using harmonic grey-scale imaging. We performed a study on a flow phantom using a SONOS 5500 (1.8–3.6-MHz harmonic imaging) and Levovist™ as the ultrasound (US) contrast agent (UCA). We applied the UCA in six different doses (0.1 to 3.0 mL) and used eight different flow-rates (180 to 540 mL/min). Additionally, we performed a study on dog brain using Levovist™ boluses of 1.5 mL and 3 mL. We evaluated the influence of dose and flow-rate on the parameters of the time-intensity curve: peak signal intensity (PSI), area under the curve (AUC) and mean transit time (MTT). Along with an increase of the Levovist™ dose, the AUC and the PSI increased only in the dose range between 0.1 and 0.5 mL Levovist™; further increase led to no change of parameters. Flow-rate showed no influence on AUC, MTT or PSI. The dye-dilution theory is not a useful theoretical model for the analysis of perfusion using harmonic grey-scale imaging. A possible explanation for this effect is the bubble saturation. (E-mail: seidel_g@neuro.mu-luebeck.de)
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
