Abstract
The quantification of cerebral hemodynamics, comprised of cerebral blood flow (CBF), cerebral blood volume (CBV) and permeability-surface area product (PS) as a measure of blood-brain barrier permeability in MS lesions in the brain is challenging. With conventional dynamic susceptibility weighted MRI, several issues with quantification arise, in particular in areas with blood-brain barrier disruption. In this study, we investigate the feasibility of a rapid 3D T1-weighted dynamic contrast-enhanced (DCE) MRI measurement, providing coverage of the entire neurocranium, in combination with a two-compartment modelling approach for the quantification of CBF, CBV and PS as a measure of blood-brain barrier leakage in contrast-enhancing (CE) lesions and in normal-appearing white matter (NAWM) in patients with multiple sclerosis (MS).
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