Abstract

Multimorbidity is an urgent problem of modern medicine, associated with a greater severity and more serious prognosis of diseases, a large number of complications, difficulty and the high cost of diagnosis and treatment. The study of the quality of life of patients with multimorbidity is necessary for the competent distribution of health resources. Aim of the study was to investigate the effect of transnozologic multimorbidity (TMM) on the components of quality of life (QoL) in patients of a therapeutic clinic. Material and methods . A total of 116 patients, men and women aged 20 to 75 years were examined at the clinic of the Federal Research Center for Fundamental and Translational Medicine in Novosibirsk. TMM was evaluated by the average number of nosologies corresponding to the three-digit classification of ICD-10. Assessment of QoL indicators was carried out using the validated questionnaire SF-36. To assess the number and severity of chronic diseases in the structure of TMM, the CIRS (Cumulative Illness Rating Scale) system was used. Results . Depending on the severity of TMM, 3 groups of patients were formed – with low ( n = 42), medium ( n = 52) and high TMM ( n = 22). A comparative analysis of indicators of QoL, as well as TMM structure in 3 groups was carried out. A comparative analysis showed a significant decrease in the level of physical functioning (by 27 %), physical and mental health components (by 26.3 % and 15.8 %, respectively), and the integral indicator of quality of life (by 19.2 %) in patients with a high level TMM, compared with patients with low TMM. Correlation analysis confirmed the presence of a statistically significant relationship between an increase in TP and a decrease in the main indicators of QoL. Conclusion . An increase in the degree of TMM in patients is significantly associated with a decrease in the main indicators of QoL.

Highlights

  • Sevostyanova E.V. et al Quality of life of patients with polymorbid pathology out

  • A comparative analysis showed a significant decrease in the level of physical functioning, physical and mental health components, and the integral indicator of quality of life in patients with a high level transnozologic multimorbidity (TMM), compared with patients with low TMM

  • An increase in the degree of TMM in patients is significantly associated with a decrease in the main indicators of quality of life (QoL)

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Summary

Качество жизни больных с полиморбидной патологией

Федеральный исследовательский центр фундаментальной и трансляционной медицины 630117, г. Полиморбидность представляет собой актуальную проблему современной медицины, связанную с ухудшением по сравнению с изолированной патологией прогноза заболевания, увеличением тяжести течения, количества осложнений, трудности и стоимости диагностики и лечения. Цель исследования – изучить влияние транснозологической полиморбидности (ТПМ) на компоненты КЖ у пациентов терапевтической клиники. На базе клиники ФГБНУ «Федеральный исследовательский центр фундаментальной и трансляционной медицины» Новосибирск) проведено обследование 116 мужчин и женщин в возрасте от 20 до 75 лет. В зависимости от степени выраженности ТП сформировано 3 группы больных: с низким (n = 42), средним (n = 52) и высоким уровнем ТПМ (n = 22). Корреляционный анализ подтвердил наличие статистически значимой связи между увеличением ТПМ и снижением основных показателей КЖ. Возрастание степени ТПМ значимо связано с уменьшением основных показателей КЖ.

Материал и методы
Findings
Интегральный показатель качества жизни

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