Abstract
SummaryChanges in health-related quality of life (QoL) due to hip, humeral, ankle, spine, and distal forearm fracture were measured in Russian adults age 50 years or more over the first 18 months after fracture. The accumulated mean QoL loss after hip fracture was 0.5 and significantly greater than after fracture of the distal forearm (0.13), spine (0.21), proximal humerus (0.26), and ankle (0.27).IntroductionData on QoL following osteoporotic fractures in Russia are scarce. The present study evaluated the impact of hip, vertebral, proximal humerus, distal forearm, and ankle fracture up to 18 months after fracture from the Russian arm of the International Costs and Utilities Related to Osteoporotic Fractures Study.MethodsIndividuals age ≥ 50 years with low-energy-induced humeral, hip, clinical vertebral, ankle, or distal forearm fracture were enrolled. After a recall of pre-fracture status, HRQoL was prospectively collected over 18 months of follow-up using EQ-5D-3L. Multivariate regression analysis was used to identify determinants of QALYs loss.ResultsAt 2 weeks, patients with hip fracture (n = 223) reported the lowest mean health state utility value (HSUV) compared with other fracture sites. Thereafter, utility values increased but remained significantly lower than before fracture. For spine (n = 183), humerus (n = 166), and ankle fractures (n = 214), there was a similar pattern of disutility with a nadir within 2 weeks and a progressive recovery thereafter. The accumulated mean QoL loss after hip fracture was 0.5 and significantly greater than after fracture of the distal forearm (0.13), spine (0.21), proximal humerus (0.26), and ankle (0.27). Substantial impairment in self-care and usual activities immediately after fracture were important predictors of recovery across at all fracture sites.ConclusionsFractures of the hip, vertebral, distal forearm, ankle, and proximal humerus incur substantial loss of QoL in Russia. The utility values derived from this study can be used in future economic evaluations.
Highlights
Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture
Loss of quality of life (QoL) after fragility fracture is significant, until recently, the numbers of studies and patients included were limited and the length of follow-up relatively short [7]. To overcome these issues and to estimate the costs and quality of life related to fractures in a number of countries across the world, the International Osteoporosis Foundation initiated the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS) in 2007
Results of the ICUROS [8, 9] showed that fragility hip, vertebral, and distal forearm fractures resulted in substantial QoL loss directly after fracture
Summary
Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing to an increased risk of fracture. Loss of quality of life (QoL) after fragility fracture is significant, until recently, the numbers of studies and patients included were limited and the length of follow-up relatively short [7]. To overcome these issues and to estimate the costs and quality of life related to fractures in a number of countries across the world, the International Osteoporosis Foundation initiated the International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS) in 2007. Results of the ICUROS [8, 9] showed that fragility hip, vertebral, and distal forearm fractures resulted in substantial QoL loss directly after fracture. While QoL improved with time, 18 months after fracture, mean health state utility values (HSUVs) were lower than before the fracture in patients with hip fracture (0.66 vs. 0.77 p < 0.001) and vertebral fracture (0.70 vs.0.83 p < 0.001) [8]
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