Qual a importância das tenascinas na fisiopatologia de diversas doenças?

Abstract

Tenascins are a group of proteins that make up the extracellular matrix of different tissues. They are involved with signaling and structural functions in different organs, which justifies the development of studies on their relationship with diseases in different systems. Our objective was to shed light, through an in-depth review, of the way in which tenascins are involved in triggering various organic disorders. Each type of Tenascin is related to specific disorders. Tenascin X is involved in triggering collagen diseases, while types C and W stand out in situations of trauma, inflammation and tumors. Tenascin R is involved exclusively in the central nervous system and in neuronal migration and differentiation processes. Understanding the real role of these proteins is a valuable resource for understanding the pathophysiology of various diseases, in addition to providing research into new diagnostic methods and prospecting therapeutic targets for drug development.