Abstract
qEEG spectral analysis has been considered highly sensitive to cortical functional changes and agrees strongly with the clinical diagnosis of AD. The sensitivity of spectral analysis has ranged from 71% to 81% in several studies.1-3.ObjectiveThe aim of this study was to retrospectively evaluate whether alpha qEEG spectral peak can supplement clinical examination by constituting an independent tool to monitor treatment and follow-up of dementia progression in Alzheimer’s disease (AD). In addition, we examined the demographic data and alpha power spectra distribution of patients and elderly normal controls.MethodsqEEGs were selected from 2 groups of patients: normal controls (n=30), and patients who fulfilled criteria for mild probable AD diagnosis (n=41). The alpha qEEG spectral analysis and MMSE were performed once or twice a year.ResultsIn our groups, MMSE scores and qEEG alpha spectral peak were unchanged (no statistical differences) after anticholinesterase use where qEEG spectral peak was never lower than 8 Hz in the control group.ConclusionThis study supports two important concepts. First, 8 Hz alpha appears to be the lowest awake spectral peak compatible with normality. And finally, in a clinical context, qEEG is a valuable diagnostic tool that could prove useful for Dementia follow-up.
Highlights
Abstract – quantitative electroencephalography (qEEG) spectral analysis has been considered highly sensitive to cortical functional changes and agrees strongly with the clinical diagnosis of Alzheimer’s disease (AD)
E finalmente, em contexto clínico, EEG quantitativo (EEGq) é uma ferramenta que pode ser útil no seguimento da de Demência
We proposed that qEEG spectral peak could represent an independent tool to perform Alzheimer’s disease follow-up after medication
Summary
Objective: The aim of this study was to retrospectively evaluate whether alpha qEEG spectral peak can supplement clinical examination by constituting an independent tool to monitor treatment and follow-up of dementia progression in Alzheimer’s disease (AD). A análise do pico espectral do alfa no EEGq e o Mini-Exame do Estado Mental foram realizados uma ou duas vezes no ano. Palavras-chave: eletroencefalografia quantitative, análise espectral, demência, doença de Alzheimer, queixa de memória, cognição, EEGq. As the aging population continues to grow at a vigorous pace, the prevalence of neurodegenerative diseases is rising worldwide. The advance in quantitative electroencephalography (qEEG) plays a significant role in EEG-based clinical diagnosis and studies of brain function, revealing new possibilities for clinical application in cognitive and behavioral areas. We proposed that qEEG spectral peak could represent an independent tool to perform Alzheimer’s disease follow-up after medication
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