Abstract
Background:Pyrethroid exposure in the household environment affects children directly via inhalation or dermal exposure. Hand wipes can effectively predict pyrethroid exposure to young children along with the children’s activities. The main purpose of this study is to identify the relationship between 3-PBA metabolites, hand wipe sample concentrations and multiple exposure factors, within the population of households with young children in urban Bangkok, Thailand.Methods:Interviews were conducted with the parents of 80 children (aged 2–3 years). Urine was collected to analyze for 3-PBA metabolites and hand wipe samples were collected to analyze for cypermethrin. Both were analyzed by gas chromatography (GC/MS).Results:A Spearmen’s correlation test of the increase of 3-PBA metabolites was significantly associated with an increase in hand wipe samples (cypermethrin) in children (rs = 0.226–0.274, p-value < 0.05). The binary logistic regression test presented an association between exposure factors with 3-PBA metabolite concentration. Gender presented a significant association with 3-PBA metabolites (p-value = 0.035, OR = 0.326, 95% CI 0.115–0.926), and frequency of bare feet inside the household presented a significant association with 3-PBA metabolites (p-value < 0.01, OR = 7.072, 95% CI 1.707–29.291). In addition, exposure factors were not significantly associated with wipe sample concentration (cypermethrin) but showed high risk of exposure to young children.Conclusions:Suggestions to reduce the risk from long-term pyrethroid insecticide exposure to children living in households include increased education, awareness, and management.
Highlights
Pyrethroid exposure in the household environment affects children directly via inhalation or dermal exposure
This study aims to identify associations between 3-PBA metabolites, hand wipe sample concentrations, and different exposure factors in children living in urban Bangkok, Thailand
This study focused on young children (2–3 years old) in Bangkok, Thailand, similar to a previous study related to insecticides imported into Thailand [3]
Summary
Pyrethroid exposure in the household environment affects children directly via inhalation or dermal exposure. The main purpose of this study is to identify the relationship between 3-PBA metabolites, hand wipe sample concentrations and multiple exposure factors, within the population of households with young children in urban Bangkok, Thailand. Results: A Spearmen’s correlation test of the increase of 3-PBA metabolites was significantly associated with an increase in hand wipe samples (cypermethrin) in children (rs = 0.226–0.274, p-value < 0.05). Exposure factors were not significantly associated with wipe sample concentration (cypermethrin) but showed high risk of exposure to young children. Some evidence has been presented showing that young children aged 1–3 years old may be a high-risk group for household PYR exposure by multiple routes [3]. Young children cannot protect themselves from PYRs insecticides in households of low-income families which are not aware of health risks and toxic effects of PYR insecticide exposure. Parents should be knowledgeable and protect their children from contamination with PYR insecticides in their homes
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