Abstract
Background: This work aims at investigating the histology of hippocampus formation as structural model of information processing. The study addressed the question whether the pattern of cellular type distribution within hippocampal fields could be used as support of information processing in the hippocampus. Method: Pyramidal-shaped neurons presenting both cytoplasm and nucleus outlined clearly were measured systematically on brain slides, using a light microscope connected to a microcomputer equipped with a scanner software for measuring particles. Morphological types of cells were identified following class sizes and their distribution determined through hippocampal fields. Results: A battery of statistical tests: Sturges’ classification, class sizes distribution around overall mean, Bartlett’s sphericity test, principal components analysis (PCA) followed by correlations matrix analysis and ANOVA allowed two cellular groups to be identified in the hippocampus: large and small pyramidal-shaped cells. Conclusion: The results show that sensory information processing in the hippocampus could be built on two classes of pyramidal neurons that differed anatomically with probably different physiological functions. The study suggests combination ensembles clustering large and small pyramidal cells at different rates, as fundamental signaling units of the hippocampus.
Highlights
The comparatively simple architecture of the hippocampus formation has made it an attractive model for theHow to cite this paper: Bâ, A. (2015) Pyramidal and Granule Cells Distribution through Hippocampal Fields: An Index for Sensory Information Processing
The present study investigates morphological identification of cellular types and determines their size and distribution throughout hippocampus formation
Four statistical tests: Sturges’ classification, class sizes distribution around overall mean, principal components analysis (PCA) and analysis of variance (ANOVA) allowed two cellular groups to be identified in the hippocampus: large and small pyramidal cells
Summary
The comparatively simple architecture of the hippocampus formation has made it an attractive model for theHow to cite this paper: Bâ, A. (2015) Pyramidal and Granule Cells Distribution through Hippocampal Fields: An Index for Sensory Information Processing. (2015) Pyramidal and Granule Cells Distribution through Hippocampal Fields: An Index for Sensory Information Processing. The notion of neural code in the hippocampus appeared firstly in the O’Keefe and Nadel’s Theory, by the discovery of the hippocampal “place cells” coding physical space. These “place cells” are neighboring neurons that fire in association with a rat’s place in the environment, independent of any particular stimulus or ongoing behavior [1] [2]. There appeared the notion of dual tasking by hippocampal complex-spike cells, related to two different populations of neurons, one that codes place and another that codes the relationships between various environmental stimuli [9]. The study suggests combination ensembles clustering large and small pyramidal cells at different rates, as fundamental signaling units of the hippocampus
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