Abstract
We previously identified disease-associated common variants in IL10 and IL23R, as well as HLA-B*51, in a Behcet’s disease (BD) genome-wide association study (GWAS) performed with 311,459 SNPs in 1,215 cases and 1,278 controls from Turkey, but the disease-associated variants in these genes do not fully account for the estimated genetic contribution to disease risk.
Highlights
We previously identified disease-associated common variants in IL10 and IL23R, as well as HLA-B*51, in a Behçet’s disease (BD) genome-wide association study (GWAS) performed with 311,459 SNPs in 1,215 cases and 1,278 controls from Turkey, but the disease-associated variants in these genes do not fully account for the estimated genetic contribution to disease risk
We searched for new disease associated loci by analyzing patients with uveitis and by specifying different genetic models
We found strong evidence for an interaction between the BD-associated Class I allele HLA-B*51 and ERAP1 genotype (p=9x10−4)
Summary
We previously identified disease-associated common variants in IL10 and IL23R, as well as HLA-B*51, in a Behçet’s disease (BD) genome-wide association study (GWAS) performed with 311,459 SNPs in 1,215 cases and 1,278 controls from Turkey, but the disease-associated variants in these genes do not fully account for the estimated genetic contribution to disease risk
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