Abstract
This paper reviews the literature on purity determinations with Differential Scanning Calorimetry (DSC). These determinations are based on the van't Hoff's law of melting point depression. The aim of this presentation is to clarify the advantages and pitfalls of the method. Particular emphasis has to be placed on the validity of this law. Since in practice the ‘van't Hoff line’ generally is not as straight as it should be according to theory, the plot has to be linearized mathematically. The best-known linearization procedures are briefly discussed. The obtained purity values, however, are dependent on the applied operational factors. A discussion is presented of the effects of the instrumental conditions (heating rate) and sample conditions (like sample mass, sample particle size, sample stability in the melting region, sample purity and properties of impurities).
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