Abstract
Artemisinin, a natural compound isolated from the Artemisia annua L. plant, represents an indispensable ingredient in artemsisinin-based combination therapies (ACT) against malaria. Starting from d...
Highlights
Artemisinin (ARTE), a natural ingredient of sweet wormwood, still constitutes the most active component of novel antimalarial drugs.[1−4] Because the molecular structure of ARTE is very complex and it is difficult to achieve commercial value of the drug via implementation of the total synthesis,[5−8] plant extraction represents a primary pathway for ARTE isolation.[9]
Using the highly selective photocatalyst 9,10-dicyanoanthracene (DCA) and toluene as the reaction medium, ARTE was gained with 69% of the total solids content, with DCA, unreacted educt dihydroartemisinic acid (DHAA), and other structurally very similar and mostly not yet identified byproducts remaining as impurities in the synthesis solution
In our previous work,[16] we presented a process for isolation of artemisinin from the above-mentioned synthesis solution, the product of the photocatalytic reaction.[12]
Summary
Artemisinin (ARTE), a natural ingredient of sweet wormwood, still constitutes the most active component of novel antimalarial drugs.[1−4] Because the molecular structure of ARTE is very complex and it is difficult to achieve commercial value of the drug via implementation of the total synthesis,[5−8] plant extraction represents a primary pathway for ARTE isolation.[9]. Using the highly selective photocatalyst 9,10-dicyanoanthracene (DCA) and toluene as the reaction medium, ARTE was gained with 69% of the total solids content, with DCA, unreacted educt DHAA, and other structurally very similar and mostly not yet identified byproducts remaining as impurities in the synthesis solution
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