Punción-aspiración con aguja fina en patología mamaria: evaluación de la utilización de citología líquida

Abstract

ObjectiveLiquid-based cytology (LBC) improves specimen preservation and produces fewer artefacts than conventional cytology (CC). The objective of this study was to evaluate the results of LBC in our laboratory after one year of its use. Patients and methodsThe results of a series of 1,573 biopsy specimens prepared with LBC in a one-year period were compared with a series of 3,033 specimens prepared with CC in a 2-year period and with histological features, when available. ResultsThe diagnoses obtained with LBC were insufficient in 208 (13.2%) cases, benign in 1,160 (73.7%), hyperplasia in 70 (4.5%), suspicious in 45 (2.9%) and malignancy in 90 (5.7%). A histological correlation with the diagnosis was obtained in 264 LBC samples (17%). The concordance was 74% in the diagnosis of benign lesions, 75% in hyperplasia, and 92% in malignant lesions. In the CC series, there was correlation in 350 samples (11%). The concordance was 80% in the diagnosis of benign disease, 81% in hyperplasia, and 91% in malignant disease. The diagnostic sensitivity of CC in malignant disease was 78%, specificity was 95%, positive predictive value was 94%, and negative predictive value was 79%. The sensitivity of LBC in malignant disease was 85%, specificity was 91%, positive predictive value was 87%, and negative predictive value was 89%. ConclusionLBC decreases the number of insufficient samples but increases diagnosis of hyperplasia and suspicious lesions. Efficacy in the diagnosis of malignancy is similar between the 2 techniques.