PULSE-COR REGISTRY

Abstract

Objective: The aim of current analysis was to evaluate association of different factors with arterial stiffness and LV stiffness in patients only with essential arterial hypertension (AH). Design and method: PULSE-COR is one center registry started in 2011 and still running. We included 779 (50%) were subjects with AH. Final analysis included 320 patients that underwent all necessary diagnostic procedures from whom we have identified a separate cohort of patients (n = 283) with essential AH without any significant comorbidities. We measured carotid-femoral pulse wave velocity (cfPWV), CAVI and ankle-brachial index (ABI) by of VaSera 1500 (Fukuda Denshi, Japan), intima-media thickness (IMT) measurement, made standard echocardiography with ventricle-arterial coupling (VAC). In order to find associations we used Spearman correlation analysis. Results: Mean age was 53,6 ± 2,0 years, 17 men and 30 women. Mean body mass index 29,8 ± 1,0 m/kg2, mean systolic blood pressure (SBP) was 159,8 ± 4,5 mmHg, diastolic BP (DBP) was 97,9 ± 2,6 mmHg, pulse BP (PBP) was 62,0 ± 3,5 mmHg and heart rate (HR) was 76,6 ± 2,2 bits per min. VAC was significantly associated with both (left and right) CAVI (R = 0,698; P = 0,012 and R = 0,683; P = 0,014, respectively). ABI was significantly associated with both E/A and E/e′ (R = 0,716; P = 0,006 and R = 0,764; P = 0,002, respectively). Ea was significantly associated with IMT (R = 0,491; P = 0,24), total cholesterol (R = 0,499; P = 0,07), low-density lipoproteins (R = 0,687; P = 0,001), cfPWV was associated with almost the same factors (R = 0,248; P = 0,001 for correlation with IMT, R = 0,382; P = 0,01 for correlation with low-density lipoproteins). Ees was significantly associated with E/A (R = 0,159; P = 0,007); E/e′ (R = −0,130; P = 0,029), end diastolic volume (R = 0,644; P < 0,001). Conclusions: We have found that VAC was significantly associated with arterial elasticity (CAVI), but we have not any correlation with CAVI for none of its component (Ea or Ees). Arterial elastance (Ea) was associated with similar factors as large arteries stiffness (cfPWV). Ventricle elastance instead was associated with diastolic dysfunction.