Abstract
BackgroundVital pulp therapy aims at maintaining the pulp tissue injured but vital. Thus, the use of capping materials that induce tissue regeneration is a great current trend. This study aims to evaluate clinically and radiographically the pulp repair after the use of dentin-pulp biostimulation membrane in primary teeth.MethodsFour hundred and sixty-eight teeth from children aged between 5 and 9 years old, both genders, with deep caries lesion with pulp involvement, but no furcal impairment and any sign of necrosis will be selected. The vital pulp therapy will be performed with mineral trioxide aggregate (control group) and dentin-pulp biostimulation chitosan membrane (BBio group). The clinical and radiographic outcomes will be assessed at 12 and 24 months after treatment. The thickness of the dentin barrier will be verified through Image J2 software. The Wilcoxon signed rank test and Mann-Whitney test will respectively compare the intra- and intergroup clinical and radiographic outcomes. Paired t test and independent t test will respectively compare the intra- and intergroup radiographic measurements. The logistic regression will be applied, and the degrees of this association will be measured using odds ratio (OR) and 95% confidence interval (95% CI).DiscussionTherefore, this study protocol aims at new perspectives of vital pulp therapy of primary teeth by employing new easy-handling, low-cost material to keep viable the pulp tissue capable of regenerating and maintain the physiological process of deciduous tooth exfoliation.Trial registrationBrazilian Registry of Clinical Trials RBR-6vr58b. Registered on 17 February 2019.
Highlights
Vital pulp therapy aims at maintaining the pulp tissue injured but vital
This study aims to evaluate clinically and radiographically the pulp repair after the use of a new dentin-pulp biostimulation chitosan membrane in primary teeth with deep occlusal and occlusoproximal cavities reaching more than 3/4 of the total thickness of carious dentin evaluated by periapical radiograph, with at least two thirds of root length
Many pulpectomy and extractions could be avoided whether pulp regeneration therapies would be tailored for primary teeth [4, 38]
Summary
The use of capping materials that induce tissue regeneration is a great current trend. Mineral trioxide aggregate (MTA) is the gold-standard material for clinical procedures of vital pulp therapy of primary teeth because of higher success rates in systematic reviews and meta-analysis [6,7,8,9,10]. The search for new bioactive, biodegradable, and nontoxic material is constant [4, 20]. In this scenario and given its commonness regenerative, antiinflammatory properties, and biocompatibility, chitosan, a natural polymer derivative of chitin, has found several applications in dentistry nowadays [21,22,23]
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