Pulmonary function tests in people with metabolic syndrome

Abstract

Background: Metabolic syndrome is a cluster of cardio- metabolic risk factors characterized by abdominal obesity, insulin resistance, and chronic systemic inflammation. Objectives: i)To assess pulmonary function in people with metabolic syndrome ii)To assess whether each component of metabolic syndrome affects pulmonary function indices. Methodology: After a detailed history and physical examination, subjects underwent investigations like fasting lipid profile, fasting blood sugars, electrocardiogram, chest x-ray, pulmonary function tests, 2D echocardiography. Results:In both groups majority had normal pulmonary function tests.In metabolic syndrome group, most common abnormal PFT reported was mild restriction.The pattern of pulmonary function tests is mild restriction in metabolic syndrome subjects.In the overall study group, hypertension, fasting glucose, body mass index, waist circumference have significant negative correlation with both FEv1 and FVC and triglycerides have significant negative correlation with FVC whereas total cholesterol has significant negative correlation with FEV1.Only HDL-c has strong positive correlation with FVC .Conclusion: The findings in this study highlight the notion that FVC and FEV1 are inversely associated with the accumulation of metabolic syndrome components and also independently associated with each component of metabolic syndrome.