Abstract
Purine Rich Box-1 (PU.1)/ SFFV Proviral Integration Site-1 (Spi-1) is an Ets-family transcription factor, which was first characterized as an oncogene in Friend's murine erythroleukemia, and subsequently, as a transcriptional regulator of myeloid promoters. PU.1 has since emerged as a central regulator of all hematopoietic cell lineages. PU.1 is essential for terminal myeloid cell differentiation, B and T cell development, erythropoiesis and hematopoietic stem cell maintenance. These pleiotropic functions are reflected by its complex and dynamic expression pattern during hematopoiesis. Factors regulating this complex expression are only beginning to be revealed. Interestingly, recent work has provided strong evidence that suppression of PU.1 function is critical for the leukemic transformation of myeloid cells, both in mouse and man. Thus PU.1 is a multi-faceted protein that controls numerous normal and pathogenic functions within the hematopoietic system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The International Journal of Biochemistry & Cell Biology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
