Abstract
Abstract Background Amiodarone is commonly associated with thyroid dysfunction. Incidence of amiodarone induced thyroid dysfunction is variable in the literature and prognosis of patients who developed amiodarone induced thyroid dysfunction compared to euthyroid patients is still unclear. Results During a mean follow up of 7.4 years, 777 (3.9%) developed thyrotoxicosis (incidence rate 3.96 per 1000 person years) and 2,225 (11.3%) developed hypothyroidism (incidence rate 11.93 per 1000 person years). Patients with thyrotoxicosis or hypothyroidism had a lower MACE rate compared to euthyroid patients (45.2% vs. 50.2% and 48.5% vs. 50.2%). Multivariate analysis revealed that older age (>65 years), chronic kidney, ischemic heart disease and chronic obstructive lung disease were independent risk factors of MACE. Patients who developed thyrotoxicosis or hypothyroidism had a lower risk of MACE than euthyroid patients (HR=0.75 [95% CI: 0.68-0.83] and HR=0.73 [95% CI: 0.69-0.77]). Conclusion The incidence of amiodarone-induced thyrotoxicosis was higher compared to hypothyroidism. The patients with thyrotoxicosis or hypothyroidism had lower cardiovascular events in patients treated with amiodarone. Presentation: Sunday, June 12, 2022 12:30 p.m. - 2:30 p.m.
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