Abstract
BackgroundIntravascular fasciitis (IVF) is a rare benign condition characterised by reactive myofibroblastic proliferation arising from the superficial or deep fascia and involving arteries and/or veins. It is a distinct variant of the more common condition of nodular fasciitis, which possesses similar clinical and histological features to IVF, but lacks vascular invasion. A thorough review of the literature revealed 26 reported cases of IVF.Case presentationWe report a case of IVF in a 16-week pregnant lady affecting the hypothenar eminence of the hand associated with the ulnar artery.ConclusionThe characteristic involvement of muscular arteries and veins by reactive myofibroblastic proliferation in IVF suggests a malignant component and often leads to an inappropriate diagnosis for this benign condition. We propose that hormone-related changes associated with pregnancy may play an important role in the aetiopathogenesis of this myofibroblastic lesion.
Highlights
Intravascular fasciitis (IVF) is a rare benign condition characterised by reactive myofibroblastic proliferation arising from the superficial or deep fascia and involving arteries and/ or veins
Case presentation: We report a case of IVF in a 16-week pregnant lady affecting the hypothenar eminence of the hand associated with the ulnar artery
We propose that hormone-related changes associated with pregnancy may play an important role in the aetiopathogenesis of this myofibroblastic lesion
Summary
IVF is a benign myofibroblastic proliferative lesion that involves arteries and/or veins, a feature distinguishing it from other pseudosarcomatous proliferative lesions. It may be mistaken for a malignant sarcomatous invasion of the vasculature. 3. Freedman PD, Lumerman H: Intravascular Fasciitis: Report of two cases and review of the literature. 4. Ito M, Matsunaga K, Sano K, Sakaguchi N, Hotchi M: Intravascular fasciitis of the forearm vein: A case report with immunohistochemical characterisation. 5. Kahn MA, Weathers DR, Johnson DM: Intravascular fasciitis: A case report of an intraoral location. 7. Samaratunga H, Searle J, O'Loughlin B: Intravascular Fasciitis: A case report and review of the literature. 9. Enzinger FM, Weiss SW: Benign fibrous tissue tumours.
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