Abstract
Proton magnetic resonance studies of the binding of the antileprosy drug, diamino diphenyl sulphone (dapsone or DOS) with the model membrane, dipalmitoyl phosphatidyl choline (DPPC) in water, have been undertaken. The results indicate that the drug molecules bind to the head group of DPPC, reducing thereby, the number of sites available for water to bind to DPPC. This results in the sharpening of the proton magnetic resonance line of water on addition of the drug. The results also indicate that the motion of the alkyl chain, as also that of the head group, become more restricted as a result of the binding of the drug with DPPC.
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