Abstract
Diffuse musculoskeletal pain is a very frequent and non-specific symptom. Etiologically can be related or not with systemic diseases (endocrine disorders, connective-tissue diseases, infections), they can be secondaries to drugs (statins) or appear within primary muscle disorders like metabolic and inflammatory myopathies. Chronic diffuse myalgias, without muscle weakness or without elevation of creatine kinase (CK) levels, will be very rarely be related to myopathy. Key differential diagnostic tools are: clinical history (onset form, progression, triggering factors, related symptoms, drug and medical history) and changes in CK profile, in case they exit. General blood test, including ions, vitamin D and thyroid function is mandatory. According to diagnosis suspicion, antibodies test and erythrocyte sedimentation rate/C-reactive protein will be requested. Muscle biopsy is necessary in those cases in which muscle weakness is observed.
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