Abstract
Turner Syndrome (TS) is a sex chromosome aneuploidy (45,X) associated with social skill difficulties. Recent clinical care guidelines recommend that the Program for the Education and Enrichment of Relational Skills (PEERS) social skills intervention programme be trialled in this population. PEERS has been successfully used in adolescents with autism spectrum conditions without intellectual disabilities. The PEERS program will be piloted with adolescents and young women with TS aged 16-20 using an uncontrolled study trial with a multiple-case series design. The program will be delivered face to face and online.The assessment battery is designed to measure social skills comprehensively from diverse informants (parent, teacher young person). It includes measures of social performance, social knowledge and social cognition. Parents and young people taking part in the intervention will also feedback on the acceptability and feasibility of the pilot. The outcomes of this small scale pilot (n=6-10) will be used to adapt the programme based on feedback and estimate the sample for a future randomised controlled trial.
Highlights
Turner Syndrome (45,X; Turner syndrome (TS)) is one of the most common sex chromosome aneuploidies, with an incidence of 1 in 2500 female births1
Sample size A sample size of 6–10 girls and their parents will be invited to take part in the study - this is the group size recommended by the PEERS intervention manual
This approach is appropriate given that it is a feasibility pilot conducted with a small number of participants (n=6–10), the disadvantage of the approach is that the study has low external validity, which reduces the generalizability of the findings
Summary
Turner Syndrome (45,X; TS) is one of the most common sex chromosome aneuploidies, with an incidence of 1 in 2500 female births. TS is associated with a variety of morbidities affecting nearly every bodily system, including skeletal abnormalities such as short stature, dysmorphic features, hearing difficulties, infertility, cardiac abnormalities, diabetes and thyroid problems. These difficulties have been well characterized in the literature (see Gravholt et al 20172 for the most recent review) and require clinical monitoring across the lifespan. TS females have social difficulties throughout childhood, but these become more apparent in adolescence when socialisation becomes more complex. Previous research has shown TS is associated with specific deficits in social cognitive competence, especially forming and maintaining peer relationships
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
