Abstract
The review is devoted to the analysis of literature data related to the role of proteomic studies in the study of atherosclerotic cardiovascular diseases. Diagnosis of patients with atherosclerotic plaques before clinical manifestations is an arduous task. The review presents the results of research on the new proteomic potential biomarkers of coronary heart disease, coronary atherosclerosis, acute coronary syndrome, myocardial infarction, carotid artery atherosclerosis. Also, the analysis of literature data on proteomic studies of the vascular wall was carried out. To assess the involvement of proteins in the pathological process of atherosclerosis, it is important to investigate the specific relationships between proteins in the arteries, expression and concentration of proteins. The development of proteomic technologies has made it possible to analyse the number of proteins associated with the development of the disease. Analysis of the proteomic profile of the vascular wall in atherosclerosis can help to detect possible diagnostically significant protein structures or potential biomarkers of the disease and develop novel approaches to the diagnosis of atherosclerosis and its complications.
Highlights
One of the most promising areas of molecular biology is proteomics, whose tasks include the study of gene expression protein products, including their posttranslational modifications and their comparative analysis
Assessments of the protein complex are proposed as a promising approach for more accurate diagnosis and choice of treatment tactics to prevent the development of disease complications
Proteomic biomarkers associated with risk factors for cardiovascular diseases can provide insight into the pathogenesis of cardiovascular diseases
Summary
One of the most promising areas of molecular biology is proteomics, whose tasks include the study of gene expression protein products, including their posttranslational modifications and their comparative analysis. 298 proteins associated with the pathogenesis of coronary atherosclerosis were studied in 63 people (33 with coronary heart disease and 30 in the control group).
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