Abstract
Moraxella catarrhalis is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; however, its response to iron starvation during infection is not completely understood. Here, we announce a sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) data set describing the differential expression of the M. catarrhalis CCRI-195ME proteome under iron-restricted versus iron-replete conditions.
Highlights
Moraxella catarrhalis is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; its response to iron starvation during infection is not completely understood
Peptide were extracted (75-ppm mass tolerance and 10-min retention time window), shared and modified peptides were excluded, and peptides with a confidence level of Ն99% and false discovery rate (FDR) of Յ1% were used for quantitation
Peptide peak areas were normalized to the total peak area for each run, and statistical analysis was performed as previously described [4]
Summary
Moraxella catarrhalis is a leading cause of otitis media and exacerbations of chronic obstructive pulmonary disease; its response to iron starvation during infection is not completely understood. Peptide were extracted (75-ppm mass tolerance and 10-min retention time window), shared and modified peptides were excluded, and peptides with a confidence level of Ն99% and false discovery rate (FDR) of Յ1% were used for quantitation.
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