Abstract
Normal individuals excrete 100–150 mg (10 mg/dl) total protein in the urine in 24 hr. Electrophoresis of this urinary protein may reveal 40% albumin; 40% renal tissue proteins, consisting largely of Tamm-Horsfall (TH) protein; and 20% immunoglobulins. Such a small amount of protein in normal urine is not ordinarily detectable by the heat test or by the dipstick method, but these methods are quite sensitive and may detect protein in concentrated normal urine. Proteinuria that is so detected should be confirmed by a quantitative protein analysis of 24-hr urine; the types of proteins present can be determined by simple electrophoresis. If there is an electrophoretic monoclonal peak of globulin, immunoelectrophoresis of urine should be performed to determine the types of immunoglobulins present.
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