Abstract
We compared the protein tyrosine kinase (PTK) activity in the acytosolic and particulate fractions of homogenates obtained from 10 papillary thyroid adenocarcinomas with the corresponding activity in 10 specimens from adjacent normal thyroid tissue and 8 follicular adenomas. The cytosolic PTK activity of papillary adenocarcinomas was significantly elevated compared to normal and adenoma tissue. The particulate PTK activity was also significantly elevated in the papillary adenocarcinomas. The cellular distribution of PTK activity (cytosolic activity in percentage) in normal thyroid tissue, adenomas, and papillary adenocarcinomas showed no significant difference (62%, 64% and 63% respectively). These findings indicate that elevated cytosolic PTK activity may be a potentially useful marker for papillary thyroid carcinoma.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
