Abstract
Introduction: Heat shock protein 90 (HSP90) serves as an ATP-dependent molecular stabilizer of diverse signaling proteins, including many kinases that are involved in cell proliferation and survival. Protein kinase D2 (PRKD2) is a serine-threonine kinase that belongs to the calcium/calmodulin-dependent protein kinase superfamily. We have recently shown that PRKD2 is a crucial regulator of tumor cell – endothelial cell communication in gastrointestinal tumors.
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