Abstract
Myocardial infarction (MI) is a leading cause of morbidity and mortality across the world. It manifests as an imbalance between blood demand and blood delivery in the myocardium, which leads to cardiac ischemia and myocardial necrosis. While it is not easy to identify the first pathogenic cause of MI, the consequences are characterized by ischemia, chronic inflammation, and tissue degeneration. A poor MI prognosis is associated with extensive cardiac remodeling. A loss of viable cardiomyocytes is replaced with fibrosis, which reduces heart contractility and heart function. Recent advances have given rise to the concept of natural polyphenols. These bioactive compounds have been studied for their pharmacological properties and have proven successful in the treatment of cardiovascular diseases. Studies have focused on their various bioactivities, such as their antioxidant and anti-inflammatory effects and free radical scavenging. In this review, we summarized the effects and benefits of polyphenols on the cardiovascular injury, particularly on the treatment of myocardial infarction in animal and human studies.
Highlights
Despite current optimal treatments, cardiovascular diseases (CVDs) are the most common global causes of morbidity and mortality
Polyphenols are biomolecules that originate from plants and have antioxidant and anti-inflammatory effects [9], which can modulate the activity of a wide range of enzymes and cell receptors [10]
We mainly focused on recent experimental studies exploring the effects of some polyphenols in a model of myocardial
Summary
Cardiovascular diseases (CVDs) are the most common global causes of morbidity and mortality. Inflammatory cytokines and chemokines are involved in the reparatory process, activating macrophages and triggering an expansion of the reparation of fibroblasts to secrete a collagen-based matrix This scar can protect the heart from early cardiac rupture, infarct healing is related to adverse remodeling in both the infarcted and the non-infarcted zones of the myocardium. Asform discussed inchemically this review,modified polyphenols their beneficial on treating and metabolism of various polyphenols is necessary to evaluate their biological activities within target diseases, including myocardial infarction As discussed in this review, polyphenols exert their beneficial effects on treating cardiovascular diseases, including myocardial infarction
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