Abstract
The aim of this study was to evaluate the association of education and tau burden in mild cognitive impairment(MCI) patients with suspected non-Alzheimer pathology(SNAP). We recruited 56 aMCI patients who underwent MRI, [18F]-florbetaben PET and [18F]THK-5351-PET. Among them, 25 aMCI patients turned out to be amyloid negative, measured by [18F]-florbetaben PET. Presence of neurodegeneration was assessed by hippocampal atrophy in MRI. 16 patients were aMCI with SNAP. We used education year as a proxy of cognitive reserve. Tau was assessed using [18F]THK-5351-PET for all patients at Samsung or Asan Medical Center. Cerebellar gray matter was used as a reference region and we measured regional tau standardized uptake value ratio (SUVR). We used freeSurfer-derived ROIs. Compared to amyloid (-) aMCI without hippocampal atrophy, SNAP showed higher [18F]THK-5351 uptakes in the left temporal pole, right temporal pole and right posterior cingulate regions(p=0.012, 0.001 and 0.039, respectively). Increased educational years were correlated with decreased 18F]THK-5351 uptakes in the left pars angularis region and left isthmus cingulate region?? regions. (p=0.044 and 0.036, respectively). This finding suggests that education showed protective effect on tau burdens in aMCI with SNAP.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
