Abstract
a peer-reviewed, open access online international journal which publishes original research papers. The journal welcomes submission from scholars and experts for possible publication from all over the world. The scope of the journal includes: Pharmaceutical research, chemistry and biochemistry of naturally occurring compounds, biological evaluation of crude extracts, ethnomedicine, traditional and complementary medicine, ethnopharmacology, biomedical research, Biotechnology, Evaluation of natural substances of land and sea and of plants, microbes and animals, pharmacognosy, bioavailability, clinical, pharmacological, toxicological studies and pharmacokinetics of phytochemicals, Isolation and characterization of compounds, structure elucidation, synthesis and experimental biosynthesis of natural Product as well as developments of methods in these areas are welcomed in the journal.
Highlights
Global statistics on cancer is estimated at 18.1 million cases and 9.6 million deaths in 2018 and breast cancer is one of the leading cancers causing morbidity and mortality of 2,088,849 and 626,679 respectively.[1]
Studies have reported that caffeine improves the efficacy of anticancer drugs.[22]. It is not known the potential benefit of the combination of artemisinin and caffeine for cancer prevention, it is imperative to determine their mechanism of effects in reducing the risk of cancer and these were investigated and data reported
This was an experimental design to determine the efficacy of artemisinin alone or combined with caffeine for chemo-prevention of breast tumor development and DNA-damage induced with 7,12dimethylbenzanthracene (DMBA) in Wistar Albino rats
Summary
Global statistics on cancer is estimated at 18.1 million cases and 9.6 million deaths in 2018 and breast cancer is one of the leading cancers causing morbidity and mortality of 2,088,849 and 626,679 respectively.[1]. Caffeine inhibits tumor development through antagonism of the A2AR adenosine receptor, cell-cycle arrest downregulation of phospho-Erk1/2, phospho-Akt, survivin, and anti-apoptotic Bcl-2 protein.[17,18,19,20,21] Studies have reported that caffeine improves the efficacy of anticancer drugs.[22] Despite these reports, it is not known the potential benefit of the combination of artemisinin and caffeine for cancer prevention, it is imperative to determine their mechanism of effects in reducing the risk of cancer and these were investigated and data reported.
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