Abstract
The present study was conducted to evaluate the protective role of ethanolic leaf extract of Annona muricata on dimethylnitrosamine (DMN)-induced hepatotoxicity in rat model. DMN administered rats (single dose orally, 12 mg/kg; on day 8) were pretreated with ethanolic leaf extract of Annona muricata (400 mg / kg body weight) for 7 days and sacrificed 48hrs after DMN intoxication. Results showed that DMN caused a marked rise in serum alanine aminotransferase (ALT), total cholesterol (TC), as well as marked decrease in serum total protein (TP), globulin, albumin (ALB), PCV, WBC, RBC, Hemoglobin and platelet compared to controls. However pretreatment with Annona muricata ethanolic leaf extract produced a significant decrease in the ALT and total cholesterol level and an increase in total protein, globulin, albumin and hematological parameters compared to DMN alone group. Taken these data together, it can be concluded that natural plant components such as Annona muricata leaves could protect the liver against dimethylnitrosamine (DMN)induced liver toxicity.
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